The group will bed down in Floodgate Street to get a truthful taste of what it is like to sleep rough as part of the Big Sleep Out event.
Latest predictions from the Met Office show the youngsters will have a cold night with temperatures set to plummet to 2C.
Young people are one of the groups increasingly facing homelessness and many of those taking part are worried about their future.
Shanze Shah, one of the youngsters preparing for the Big Sleep Out, said: “Many of my friends are worried about finding jobs and whether we’ll be able to move out of home.
“This is a great way to raise awareness of the increasing number of young people who face being homeless and help homeless charities across Birmingham.”
The young people taking part are members of The Challenge Society, a scheme that inspires young people to make a difference in their community, after completing The Challenge, a programme run by The Challenge Network as part of the National Citizen Service (NCS).
As well as raising awareness of the problems homeless people face, the event will also be used to collect food, clothing and donations which will be distributed to the homeless charities across the city.
On the same night, around 3,000 youngsters will be sleeping rough nationwide.
Craig Morley, chief executive of The Challenge Network, said: “This summer over 9,000 young people completed The Challenge as part of the NCS, and it’s great to see so many of the young people we worked with staying involved through The Challenge Society and taking action in their own communities.”
The event will be attended by volunteers from charity Trident Reach, which supports vulnerable individuals in the Midlands, and Housing Association Midland Heart.
Cardboard boxes have been donated by Morrisons supermarket on Hagley Road.
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